Read e-book online The calcitonin gene-related peptide family: form, function PDF

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By Deborah L. Hay,Ian M. Dickerson

ISBN-10: 9048129087

ISBN-13: 9789048129089

ISBN-10: 9400791801

ISBN-13: 9789400791800

In 1925, J. B. Collip (1925) suggested that extracts of parathyroid gland contained an task that raised calcium degrees within the blood of parathyroidectomized animals, and steered that this used to be because of a hormone produced within the parathyroid gland. the tale of parathyroid hormone discovery used to be indicative of ever-increasing sophistication in pattern guidance and protein isolation innovations. This paper resolved prior controversies over the functionality of the parathyroid glands and c- trol of blood calcium. The 12 months 1961 was once a banner 12 months for parathyroid study, within which the peptides parathyroid hormone and calcitonin have been purified, and during which it used to be steered that calcitonin may perhaps reduce blood calcium (Copp and Cameron 1961). In 1982 it was once found that during neurons the first RNA transcript for calcitonin might be alternatively-spliced to offer calcitonin gene-reated peptide (CGRP), and soon thereafter amylin (previously named islet amyloid polyp- tide, IAPP) used to be pointed out and proven to have homology to CGRP. on the grounds that then a and b CGRP were delineated and adrenomedullin and intermedin came across, and this kinfolk of homologous peptides has emerged. This relations of peptide hormones has a various and continuously increasing variety of significant physiologic features, together with legislation of blood calcium, vascular rigidity, feeding habit and discomfort recognition.

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The calcitonin gene-related peptide family: form, function and future perspectives by Deborah L. Hay,Ian M. Dickerson


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