By Janet D. Rowley,Michelle M. Le Beau,Terence H. Rabbitts
This quantity collates global specialists’ insights into the molecular biology of melanoma chromosomes, their abnormalities and the following mobile effects. Exploring issues concerning oncogenes, akin to by way of chromosomal translocations, different genome rearrangements and somatic mutations, this e-book is a evaluate of the sector of melanoma genetics that presages a brand new period, as entire genome sequencing turns into extra accessible.
The paintings starts off with a glance at ancient issues, comparable to the research of metaphase chromosomes utilizing microscopy and marking innovations, advances within which supplied our first vast glimpse into the genetic anatomy of a malignant cellphone. Readers will find out about the applying of DNA molecular cloning recommendations within the Nineteen Eighties, that resulted in the identity of the genes serious about the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the position of oncogenes and tumour suppressor genes in melanoma aetiology through chromosomal changes and which introduced a box in melanoma genetics.
Subsequent chapters deliver the reader brand new via reviewing fresh advancements within the box, with devoted sections on leukaemia/lymphoma, sarcomas and epithelial tumours.
Contributions characteristic quite a few color tables and illustrations and this quantity will offer a foundation for figuring out melanoma chromosomes for a few years to come.
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Extra resources for Chromosomal Translocations and Genome Rearrangements in Cancer
Chromosomal Translocations and Genome Rearrangements in Cancer by Janet D. Rowley,Michelle M. Le Beau,Terence H. Rabbitts